In the human body, resveratrol activates the protein deacetylase sirtuin 1 (SIRT1) gene. Sirt1 acts as a cardioprotective molecule that protects against ageing processes, induces resistance to hypertrophic and oxidative stress, inhibits the apoptosis of cardiomyocytes and regulates energy metabolism in the heart.
A recent review published in a prestigious journal by Zhang et al, 2021, shows that in the brain, resveratrol supports healthy neuronal function by improving signaling pathways and alleviating cellular stress, potentially protecting against cognitive decline. For heart health, it activates AMPK, a key regulator of energy metabolism, and improves cellular energy production, while reducing inflammation to support overall cardiovascular function. Resveratrol's anti-inflammatory effects extend throughout the body, helping to regulate proteins such as TNF-α and IL-6, which play a role in chronic disease. It also inhibits signaling pathways that promote the growth and spread of cancer cells and reduces the oxidative stress and inflammation that contribute to tumor development.
