Betaine Trimethylglycine (TMG)

4.9 (45 reviews)

Betaine, a derivative of the amino acid glycine, is an ammonium compound containing three methyl groups

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What makes our betaine trimethylglycine (TMG) special

Sustainably sourced from sugar beets, our betaine powder is designed to support optimal homocysteine metabolism and maximize performance.

  • Supports homocysteine metabolism
  • pure crystalline formula with high bioavailability
  • A well-researched, bioavailable form of choline
  • Sustainable production from sugar beets
  • 100% vegan and GMO-free, independently tested by German laboratories

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At Eternal Vitality, we place the highest priority on transparency regarding the quality of our products. Every single product undergoes rigorous testing by both our manufacturer and independent laboratories in Germany.

Quality Assurance

At Eternal Vitality, we place the highest priority on transparency regarding the quality of our products. Every single product undergoes rigorous testing by both our manufacturer and independent laboratories in Germany.

More information

At Eternal Vitality, we place the highest priority on transparency regarding the quality of our products. Every single product undergoes rigorous testing by both our manufacturer and independent laboratories in Germany.

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Sandra H.

"Ordering from Eternal Vitality was a breeze, and my order arrived quickly. The quality of the products is excellent. I'm particularly impressed by the transparency and the top-notch customer service. Highly recommended!"

ISO-certified in Germany Each batch is tested in certified German laboratories
Free shipping Within Germany and, for orders of €150 or more, to the rest of the EU
10,000+ customers Trusted by a growing longevity community
Scientifically sound Based on current research

Betaine contributes to normal homocysteine metabolism

Betaine contributes to normal homocysteine metabolism

Elevated homocysteine levels are associated with an increased risk of thrombosis and cardiovascular disease, as homocysteine damages endothelial cells, promotes oxidative stress, and enhances blood clotting. Studies show that lowering homocysteine levels by taking betaine can reduce the risk of atherosclerosis and cardiovascular events.

Betaine, also known as trimethylglycine (TMG), is a well-tolerated derivative of an amino acid that occurs naturally in the body and helps process a chemical called homocysteine. Homocysteine plays a crucial role in thenormal functioning of many parts of the body, including the blood, bones, eyes, heart, muscles, nerves, and brain.

Note: Betaine contributes to normal homocysteine metabolism. The beneficial effect is obtained with a daily intake of at least 1,500 mg of betaine. Do not exceed the recommended daily intake of 2,500 mg.

What is TMG Betain?
This is how betaine supports homocysteine metabolism
The manufacturing process explained
Ingredients & Quantity
What is TMG Betain?

Betaine – the natural methyl donor derived from sugar beets

Betaine, also known as trimethylglycine (TMG), is a naturally occurring substance in the body that is found in foods such as spinach, beets, and whole-grain products. In the human body, it plays a central role in the so-called methylation process: It donates a methyl group (CH₃) to homocysteine and, with the help of the enzyme betaine-homocysteine methyltransferase (BHMT), converts it into the harmless amino acid methionine.

This is how betaine supports homocysteine metabolism

This is how betaine supports homocysteine metabolism

The name trimethylglycine refers to its molecular structure: three methyl groups bonded to a glycine molecule. This structure makes betaine a potent methyl donor. Its primary function is to transfer a methyl group to homocysteine and convert it into methionine.

This conversion takes place primarily in the liver and reduces the accumulation of homocysteine, elevated levels of which are associated with cardiovascular risks. In addition, betaine supports the efficient production of S-adenosylmethionine (SAMe)—a compound that is essential for biochemical processes such as cell repair and mood regulation.

The manufacturing process explained

Anhydrous betaine TMG derived from high-purity sugar beets

Betaine is extracted from sugar beets using a natural extraction process—one of the purest and most sustainable sources of this active ingredient. The final product is in an anhydrous, crystalline form, resulting in a particularly stable and bioavailable compound. This process is free of synthetic solvents and additives—the powder contains only pure betaine (trimethylglycine).

  • Made from high-purity sugar beets
  • Anhydrous, crystalline form with high bioavailability
  • Ethical and 100% sustainable production
  • 100% vegan, GMO-free, independently tested in German laboratories
  • Fully stabilized for optimal storage
Ingredients & Quantity

What's included in each daily serving

Ingredients & Serving Suggestions

Contains 2,500 mg of betaine trimethylglycine per daily dose ( - NRV*)

Ingredients: Betaine (Trimethylglycine)

Recommended intake: Take 2,500 mg daily with plenty of water. This is equivalent to three scoops of the included size L (approx. 850 mg each).​

Features: vegan, sugar-free, lab-tested

*Nutrient Reference Values in accordance with EU Regulation 1169/2011

Storage: Store in a tightly sealed container in a cool, dry place, away from direct sunlight. The included silica gel is used to control moisture—please do not open or consume it.

Research on betaine

Study:
Betaine lowers elevated homocysteine levels and supports heart health
Read more

A study by Lever M. and Slow S. (2010) confirms the role of betaine as an important osmolyt and methyl group donor, which is obtained through diet or the oxidation of choline. Betaine deficiency is associated with metabolic disorders such as diabetes, lipid metabolism disorders, and cardiovascular diseases. The study highlights that people with increased betaine loss in urine, in particular, may benefit from supplementation. The results underscore betaine’s potential to support healthy homocysteine metabolism.

Study:
Betaine reduces the breakdown of immune cells after intense exercise
Read more

The study by Yang M. et al. investigated whether taking betaine for two weeks helps reduce cellular damage and fatigue following intense endurance training. The result: Betaine was able to reduce the breakdown of certain immune cells (apoptosis) after exercise, but had no effect on oxygen consumption, physical performance, or protection against oxidative stress. The results underscore betaine’s potential to support the immune system during physical exertion.

Study:
Betaine reduces inflammation and lowers the risk of metabolic syndrome in athletes
Read more

A study by Nobari H. et al., 2021, investigated whether 14 weeks of betaine supplementation in young professional soccer players during the competitive season could reduce inflammatory markers and changes in blood counts. The results show that betaine was able to lower the concentration of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and stabilize the immune system. This suggests a potential protective effect against overexertion and exhaustion. The results underscore betaine’s potential to support inflammation regulation and metabolic health.

Study:
Reduces oxidative stress and the risk of chronic diseases caused by free radicals
Read more

Thestudyinvestigated whether taking betaine for two weeks helps reduce cellular damage and fatigue following intense endurance training. The results showed that betaine reduced the breakdown of certain immune cells (apoptosis) after exercise, but had no effect on oxygen consumption, physical performance, or protection against oxidative stress.

Study:
Maintains the water balance in cells and ensures optimal cell function
Read more

Thisstudyconfirms the role of betaine as an important osmolyt and methyl group donor, which is obtained through diet or the oxidation of choline. Betaine deficiency is associated with metabolic disorders such as diabetes, lipid metabolism disorders, and cardiovascular diseases, and certain population groups—particularly those with increased betaine loss in the urine—may benefit from supplementation.

Note
Note on the research literature
Read more

These statements have not been authorized by the European Commission. All benefits mentioned are based on scientific studies published in reputable journals.

Selected reviews of Betain

Find out how satisfied our customers are.

It's great for blood pressure and supports overall health.

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Björn A.

Verified by Amazon

Good quality

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Heike P.

Verified by Trusted Shops

Great product, but the taste takes some getting used to

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Ingo F.

Verified by Amazon

Fast delivery and a great product, just as expected!

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Michael W.

Verified by Amazon

Very economical and more affordable than the competition.

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Daniel E.

Verified by Amazon

Product as described, fast shipping—I’d definitely buy again!!

frifrhsn

Verified by eBay

Fast delivery, great product, good value for money, and high quality. Individually packaged in plastic containers for easy storage and convenient handling. Highly recommended seller.

zezcone

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Frequently Asked Questions About TMG Betain

How is Betain TMG manufactured?

Our betaine is obtained from sugar beets through a natural extraction process. The resulting crystalline compound is characterized by high purity and excellent bioavailability.

How do I take betaine TMG?

Take 2,500 mg daily—equivalent to three scoops of the included size L (approx. 850 mg each)—with plenty of water. Do not exceed the recommended daily intake.

How should Betain TMG be stored?

Store in a cool, dry place with the lid tightly closed, and protect from direct sunlight. The included silica gel is used to control humidity—please do not open or consume it.

What should you keep in mind during pregnancy, while breastfeeding, or when taking medication?

If you are pregnant, breastfeeding, taking medication, or under a doctor’s care, consult a doctor before use. If side effects occur, stop use and seek medical advice immediately. Keep out of reach of children.

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TMG Betain Test Reports

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide

NMN241104

NMN Uthever NMN Nicotinamide Mononucleotide